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Sialorrhea: a review of a vexing, often unrecognized sign of oropharyngeal and esophageal disease

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The higher levels of ROS can also be caused by oncogenes such as constitutively active isoforms of RAS , and oncogenic K-RAS have been found to be necessary for precancerous lesions in the pancreas and for lung adenocarcinoma formation [35,36]