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(2018, Current Pharmaceutical Design ), showed accelerated tendon-to-bone healing and reduced inflammation markers at doses roughly equivalent to 1-10 mcg/kg
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To support this hypothesis, several studies claimed that autoreactive T cells specific for CII were not identified from either RA joints or the CIA model [44,45], which was further corroborated by another study using DR4 + CII peptide tetramer [46]
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