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Ambitious protocols integrate direct measurements: Electrophysiology LTP (Long-Term Potentiation) hippocampal on CA1 slices, gold standard of synaptic plasticity

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GSH's free thiol (pKa ~9) acts as a reductant: glutathione peroxidase uses two GSH molecules to reduce H₂O₂ or lipid peroxides (producing GSSG and water/alcohol), and NADPH-dependent glutathione reductase regenerates the reduced form