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At physiological levels, they serve as signaling molecules that promote exercise-induced adaptations, such as mitochondrial biogenesis via PGC-1α and upregulation of intrinsic antioxidant systems

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Few ideal properties of the drug that can be administered transdermally require that drug should be essentially non-irritating, dose should be preferably up to 20 mg or less and partition coefficient in octanol / water should be between 1 to 4