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While p16 ink4a and SA-β-Gal are widely used in aging studies, emerging evidence suggests that p21 (a cyclin-dependent kinase inhibitor) may be a more robust marker of senescence in human kidney disease, particularly in contexts of chronic injury and fibrosis (Knoppert et al., 2023

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Our findings align with these previous studies, leading us to hypothesize that GSH levels are higher in the tumor tissues of chemotherapy-resistant breast cancer patients compared to chemotherapy-sensitive patients

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