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Analysis of mitochondrial respiration in isolated primary ACMs from C57BL/6 mice treated with chow diet enriched with tesaglitazar and resveratrol showed restoration of mitochondrial respiration compared with mice treated with tesaglitazar alone, as shown by improved maximal respiration and spare respiratory capacity (Figure 3, E and F)

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Viability was assessed using the MTT assay (see Section 4.1 of Alvetex Scaffold 96-well plate: Instructions for Use and Sample Applications) and percentage viability was determined by comparing to a non paracetamol treated control (designated 100% viability)