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Minoxidil's mechanism — a systemic vasodilator with no follicle specificity — means side effects can extend well beyond the scalp: unwanted facial hair, scalp irritation, contact dermatitis, and (in rare cases) cardiovascular changes from systemic absorption.6 GHK-Cu, as an endogenous peptide acting locally on the cells where it's applied, has no documented systemic side effects and no withdrawal phenomenon when discontinued