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In certain embodiments of such auris-compatible formulations or compositions that comprise a dye, the ability to visualize a controlled release otic formulation or composition comprising a dye in an ear meets a long standing need for suitable testing methods that are applicable to the development of intratympanic otic formulations or compositions suitable for human use

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The two also work through different biological pathways, which is part of why researchers have studied them as potentially complementary rather than as direct substitutes