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As a substrate, the inositol derivative PIP 2 acts as a “metabolic sensor” and interacts with the Kir6.2 and SUR1 subunits of ATP-sensitive K + channels (K ATP ), stabilizing the open state of the channel (as opposed to ATP, which stabilizes the closed state of the channel), which is an important mechanism of the pancreatic release of insulin [176,177,178,179]
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Acknowledgements This research was supported by the Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2017M3D1A1039377)
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